introduction to ocular Experimental medicine

Ocular pathology is a rare but beautiful skill to learn and to develop further. The specificities of an eye make it a particular organ protected from the rest of the body with an immunological privilege. Knowing your anatomy is crucial in order to interpret experimental induced changes and potential adversities.

when developing an ocular drug it’s important to align with the specificities of the Laboratory animal anatomy preferable as close to the human anatomy. the presence of the fovea can make the difference when submitting your data to the regulatory authorities as well the knowledge & interpretation of the observed background data.

Pathological evaluations do remain semi-qualititative observations and opinions may differ between pathologists. often a consensus can be reached between pathologists during peer-reviews.

toxicological pathology expertise in ocular drug development

• revision & interpretation of Experimental study protocols

• Ocular necropsy procedures

• histology:

  • quality checks

  • special Histology technics & protocols

  • fovea location

• Histopathological evaluation incl. Historical control data, Background lesions, interpretations, & reporting

• validation experimental studies, in vitro, in vivo, & post-mortem

• GLP peer-reviews

• due Diligence expertise

• Regulatory support with your IND packages

board-certified ocular toxicology

• small molecules, biologics, medical devices, gene/vector transfer, stem cells, & drugs preventing photoreceptor loss

• All types animals & animal models for human ocular diseases

• Routes of administration: instillation, sub-conjunctival, intra-vitreal and (sub)retinal